Download e-book for kindle: Aging Research in Yeast: 57 (Subcellular Biochemistry) by Michael Breitenbach,S. Michal Jazwinski,Peter Laun

By Michael Breitenbach,S. Michal Jazwinski,Peter Laun

ISBN-10: 9400725604

ISBN-13: 9789400725607

ISBN-10: 9400794207

ISBN-13: 9789400794207

This quantity contains contributions by means of the best specialists within the box of yeast getting older. Budding yeast (Saccharomyces cerevisiae) and different fungal organisms supply versions for getting older examine which are correct to organismic getting older and to the getting older tactics taking place within the human physique. Replicative getting older, within which purely the mummy mobile a while whereas the daughter mobilephone resets the clock to 0 is a version for the getting older of stem mobile populations in people, whereas chronological getting older (measured by way of survival in desk bound section) is a version for the getting older tactics in postmitotic cells (for example, neurons of the brain). so much mechanisms of getting older are studied in yeast. between them, this ebook discusses: mitochondrial theories of getting older, emphasizing oxidative rigidity and retrograde responses; the function of autophagy and mitophagy; the connection of apoptosis to getting older strategies; the position of uneven segregation of wear and tear in replicative getting older; the function of replication rigidity; and the function of the cytoskeleton in getting older. glossy tools of yeast genetics and genomics are defined that may be used to look for aging-specific features in a genome-wide impartial model. The similarities within the pathology of senescence (studied in yeast) and of melanoma cells, together with genome instability, are examined.

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Aging Research in Yeast: 57 (Subcellular Biochemistry) by Michael Breitenbach,S. Michal Jazwinski,Peter Laun

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